As the antidepressant effects of serotonin (5-HT) agonists and antagonists become more widely researched, the roles of different 5-HT receptor subtypes are becoming more distinguished. Serotonin has a rich neurochemistry with 14 identified receptor subtypes.1 This article focuses on two primary subtypes, 5-HT1AR and 5-HT2AR, and their roles in brain functioning. Distinguishing the two is…


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