The cannabinoid receptor type 1 (CB1R) is a G-protein coupled receptor (GPCR), abundant in the central nervous system, that is activated by the key psychoactive component in Cannabis species, delta-9-tetrahydrocannabinol (THC).1 Beyond its well-described role in psychopharmacology, CB1R is also strongly implicated in regulating food intake, and inappropriate CB1R signalling contributes to the…