The results of a study published today in the Proceedings of the National Academy of Sciences (PNAS) suggest that activation of the serotonin 5-HT2A receptor (5-HT2AR) not be the main component in the mechanism of the antidepressant effects of psilocybin.1 More specifically, the authors propose that altered perceptions (i.e., a psychedelic experience) may not go hand in hand with psilocybin’s…


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