The serotonin 5-HT2A receptor plays a crucial role in learning and cognition and is one of the primary targets of the psychedelic drug lysergic acid diethylamide (LSD). Mice (murine) models have been used extensively to understand the complex neuropharmacology of the 5-HT2A receptor. This article is an overview of the similarities and differences between human and mouse 5-HT2A receptors and the…


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