Part one of this article series focused on multiple lines of evidence that suggest therapeutic effects of psychedelics are dependent on the serotonin 2A receptor (5-HT2AR). While it’s well established that 5-HT2AR activation is necessary for the psychedelic experience,1 it’s still up in the air whether the antidepressant and anxiolytic effects that are seen preclinically and clinically are reliant…

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