The 5-HT2A receptor is an essential component mediating the activity of classical psychedelics, those most-studied and clinically relevant, including LSD, DMT, psilocybin, and mescaline. This G-Protein Coupled serotonin receptor is essential for the changes in perception, cognition, and emotion stereotypically associated with psychedelic compounds.1 The last several years have seen a resurgence in…


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